Representative Publications
1. Wang J, Shen R, Yang K, Guo X, Yu J, Wu C, Guo XK, Hu X. Tuft cells restrain intestinal type 2 immunity through the transcription factor Spi-B. Science Immunology 2025. 10.1126/sciimmunol.ads5818
2. Yang L, He H, Guo X, Wang J, Wang W, Liang S, Shao F, Liu W, Hu X. Intraepithelial mast cells drive Gasdermin C-mediated type 2 immunity. Immunity 2024; 57:1056–1070.
3. Kou T, Kang L, Hu X. RBP-J regulates homeostasis and function of circulating Ly6Clo monocytes. eLife 2024; 12:RP88135.
4. Liu X, Han W, Hu X. Post-transcriptional regulation of myeloid cell-mediated inflammatory responses. Advances in Immunology 2023; 160:59.
5. Yang Y, Zhang Y, Xing X, Xu G, Wang Y, Chen M, Wang C, Han W, Hu X. IL-6 translation is a therapeutic target of human cytokine release syndrome. Journal of Experimental Medicine 2023; 220:e20230577. (selected to be Best of JEM 2023)
6. Li X, Zhang B, Yu S, Xue HH, Hu X. TLE3 and TLE4-coordinated colonic macrophage-CD4⁺ T cell crosstalk maintains intestinal immune homeostasis. Mucosal Immunology 2023; 16(1):50–60.
7. Xing X, Hu X. Risk factors of cytokine release syndrome: stress, catecholamines, and beyond. Trends in Immunology 2022; 44:93.
8. Guo Z, Yang H, Zhang JR, Zeng W, Hu X. Leptin receptor signaling sustains metabolic fitness of alveolar macrophages to attenuate pulmonary inflammation. Science Advances 2022; 8:eabo3064.
9. Zhang B, Zhang Y, Xiong L, Li Y, Zhang Y, Zhao J, Jiang H, Li C, Liu Y, Liu X, Liu H, Ping YF, Zhang QC, Zhang Z, Bian XW, Zhao Y, Hu X. CD127 imprints functional heterogeneity to diversify monocyte responses in human inflammatory diseases. Journal of Experimental Medicine 2022; 219(2):e20211191.
10. Yu L, Zhang B, Sacta MA, Rollins DA, Chinenov Y, Li R, Rogatsky I, Hu X. Negative elongation factor complex enables macrophage-mediated inflammatory responses by controlling expression of anti-inflammatory genes. Nature Communications 2020; 11:2286.
11. Kang L, Zhang X, Ji L, Kou T, Smith SM, Zhao B, Guo X, Pineda-Torra I, Wu L, Hu X. The colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens. Journal of Experimental Medicine 2020; 217(4):e20190762.
12. Hu X. Stereotyping in east and west: live with it or deal with it? Nature Immunology 2020; 21:234. (invited essay in press for the women scientist-focused issue)
13. Ji L, Zhao X, Zhang B, Kang L, Song W, Zhao B, Xie W, Chen L, Hu X. Slc6A8-mediated creatine uptake and accumulation reprogram macrophage polarization via regulating cytokine responses. Immunity 2019; 51:272–284.
14. Ning F, Li Y, Yu L, Zhang B, Liu Y, Zhao B, Shang Y, Hu X. Transcription factor Hes1 attenuates type I interferon-mediated immune responses via VEGF-C and WDFY1. Journal of Experimental Medicine 2019; 216:1396–1410.
15. Liang S, Guo XK, Ou J, Huang R, Xue Q, Zhang B, Chung Y, Wu W, Dong C, Yang X, Hu X. Nutrient sensing by the intestinal epithelium orchestrates mucosal antimicrobial defense via translational control of Hes1. Cell Host & Microbe 2019; 25:706–718.
16. Shang Y, Coppo M, He T, Ning F, Yu L, Kang L, Zhang B, Ju C, Qiao Y, Zhao B, Gessler M, Rogatsky I, Hu X. The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation. Nature Immunology 2016; 17:930–937.
17. Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, Outtz HH, Kitajewski J, Shi C, Weber S, Saftig P, Li YM, Ozato K, Blobel CP, Ivashkiv LB, Hu X. Notch-RBP-J signaling regulates IRF8 to promote inflammatory macrophage polarization. Nature Immunology 2012; 13:642–650.
Collaborative Publications
1. Xu H, Wang Y, Wang W, Fu YX, Qiu J, Shi Y, Yuan L, Dong C, Hu X, Chen YG, Guo X. ILC3s promote intestinal tuft cell hyperplasia and anthelmintic immunity through RANK signaling. Sci Immunol. 2025 (PMID: 40378237).
2. Wang W, Li N, Xu H, Wei S, Li Y, Ou J, Hao J, Zhang J, Dong L, Qiu Y, Hu X, Fu YX, Guo X. ILC3s regulate the gut microbiota via host intestinal galactosylation to limit pathogen infection in mice. Nat Microbiol. 2025 (PMID: 39962279).
3. Wang Y, Zhang X, Liu S, Gu Z, Sun Z, Zang Y, Huang X, Wang Y, Wang Q, Lin Q, Liu R, Sun S, Xu H, Wang J, Wu T, Wang Y, Li Y, Li H, Tang Z, Qu Y, Wu L, Hu X, Guo X, Wang F, Zhou L, He D, Qi H, Xu H, Chu C. Bi-directional communication between intrinsic enteric neurons and ILC2s inhibits host defense against helminth infection. Immunity. 2025 (PMID: 39889704).
4. Guo W, Li Z, Anagnostopoulos G, Kong WT, Zhang S, Chakarov S, Shin A, Qian J, Zhu Y, Bai W, Cexus O, Nie B, Wang J, Hu X, Blériot C, Liu Z, Shen B, Venteclef N, Su B, Ginhoux F. Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease. Immunity. 2024 (PMID: 39317200).
5. Shen X, Li X, Wu T, Guo T, Lv J, He Z, Luo M, Zhu X, Tian Y, Lai W, Dong C, Hu X, Wu L. TRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription. Cell Mol Immunol. 2024 (PMID: 38822080).
6. Wang Z, Sun Y, Lou F, Bai J, Zhou H, Cai X, Sun L, Yin Q, Tang S, Wu Y, Fan L, Xu Z, Wang H, Hu X, Wang H. Targeting the transcription factor HES1 by L-menthol restores protein phosphatase 6 in keratinocytes in models of psoriasis. Nat Commun. 2022 (PMID: 36535970).
7. Huang J, Fu L, Huang J, Zhao J, Zhang X, Wang W, Liu Y, Sun B, Qiu J, Hu X, Liu Z, Guo X. Group 3 Innate Lymphoid Cells Protect the Host from the Uropathogenic Escherichia coli Infection in the Bladder. Adv Sci. 2022 (PMID: 35018740).
8. Tian Y, Lv J, Su Z, Wu T, Li X, Hu X, Zhang J, Wu L. LRRK2 plays essential roles in maintaining lung homeostasis and preventing the development of pulmonary fibrosis. Proc Natl Acad Sci U S A. 2021 (PMID: 34446559).
9. Jiao H, Jiang D, Hu X, Du W, Ji L, Yang Y, Li X, Sho T, Wang X, Li Y, Wu YT, Wei YH, Hu X, Yu L. Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Cell. 2021 (PMID: 34048705).
10. Wang L, Gao Y, Zhang G, Li D, Wang Z, Zhang J, Hermida LC, He L, Wang Z, Si J, Geng S, Ai R, Ning F, Cheng C, Deng H, Dimitrov DS, Sun Y, Huang Y, Wang D, Hu X, Wei Z, Wang W, Liao X. Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade. Sci Transl Med. 2020 (PMID: 32908002).
11. Yu L, Zhang B, Deochand D, Sacta MA, Coppo M, Shang Y, Guo Z, Zeng X, Rollins DA, Tharmalingam B, Li R, Chinenov Y, Rogatsky I, Hu X. Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression. Nat Commun. 2020 (PMID: 32385332).
12. Xia Y, Xie Y, Yu Z, Xiao H, Jiang G, Zhou X, Yang Y, Li X, Zhao M, Li L, Zheng M, Han S, Zong Z, Meng X, Deng H, Ye H, Fa Y, Wu H, Oldfield E, Hu X, Liu W, Shi Y, Zhang Y. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 (PMID: 30270039).
13. Rollins DA, Kharlyngdoh JB, Coppo M, Tharmalingam B, Mimouna S, Guo Z, Sacta MA, Pufall MA, Fisher RP, Hu X, Chinenov Y, Rogatsky I. Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages. Nat Commun. 2017 (PMID: 29170386).
14. Zhang Y, Xu W, Guo H, Zhang Y, He Y, Lee SH, Song X, Li X, Guo Y, Zhao Y, Ding C, Ning F, Ma Y, Lei QY, Hu X, Li S, Guo W. NOTCH1 Signaling Regulates Self-Renewal and Platinum Chemoresistance of Cancer Stem-like Cells in Human Non-Small Cell Lung Cancer. Cancer Res. 2017 (PMID: 28416482).
15. Su X, Yu Y, Zhong Y, Giannopoulou EG, Hu X, Liu H, Cross JR, Rätsch G, Rice CM, Ivashkiv LB. Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation. Nat Immunol. 2015 (PMID: 26147685).
16. Qiao Y, Giannopoulou EG, Chan CH, Park SH, Gong S, Chen J, Hu X, Elemento O, Ivashkiv LB. Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling. Immunity. 2013 (PMID: 24012417).
17. Zhao B, Grimes SN, Li S, Hu X, Ivashkiv LB. TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J. J Exp Med. 2012 (PMID: 22249448).
Interviews and Essays
1. Hu X. Stereotyping in east and west: live with it or deal with it? Nature Immunology 2020, PMID: 32094643. (https://www.nature.com/articles/s41590-020-0597-5). (Invited essay for the women scientist-focused issue).
2. For immunologist Xiaoyu Hu, science is about pushing the boundaries of human knowledge by taking risks. Cell Press. 2024 (https://www.cell.com/news-do/50-inspiring-scientists-xiaoyu-hu). (Invited essay for Cell Press 50 Scientists that Inspire).
3.Van Emmenis L. Xiaoyu Hu: Let the data guide you. J Exp Med. 2024, PMID: 38477873. (https://rupress.org/jem/article/221/4/e20240407/276616/Xiaoyu-Hu-Let-the-data-guide-youXiaoyu-Hu-Let-the).
ORCID: 0000-0002-4289-6998
ResearcherID: D-5403-2017